MAGEL2 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
Research Areas: Cancer, Immunology
Applications: WB,ELISA
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Concentration: 0.7mg/mL
Swissprot: Q9UJ55
Gene Accession: NP_061939
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human MAGEL2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 59kDa
Tissue Specificity/Positive Control: Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.1 Publication
Cellular Localization: Cytosol,Endosome,early Endosome,Nucleus
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-magel2_polyclonal_antibody-35983.html
Manual Link: https://www.elabscience.com/viewpdf-35983-elabscience-E-AB-16588.PDF