Product Type: Antibody
Descritpion: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.
Research Areas: Cancer, Cell Biology, Signal transduction
Recommended Dilutions: WB 1:200-1:1000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_004762
Immunogen: Synthetic peptide of human MMP20
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 54kDa
Tissue Specificity/Positive Control: Expressed specifically in the enamel organ.
Cellular Localization: Secreted>extracellular space>extracellular matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.