NRAS Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Research Areas: Cancer, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:200-1:1000, IHC 1:50-1:200
Size: 200 uL
Concentration: 1.1mg/mL
Swissprot: P01111
Gene Accession: NP_002515
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human NRAS
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 21kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cell membrane. Golgi apparatus membrane. Shuttles between the plasma membrane and the Golgi apparatus.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-nras_polyclonal_antibody-36055.html
Manual Link: https://www.elabscience.com/viewpdf-36055-elabscience-E-AB-16660.PDF