Product Type: Antibody
Descritpion: SH2D3A (SH2 domain containing 3A), also known as novel SH2-containing protein 1, is a 576 amino acid protein that is thought to play a role in JNK activation. SH2D3A interacts with p130 Cas and is found at low levels in fetal kidney, fetal lung, placenta, adult pancreas, kidney and lung. Subject to post-translational phosphorylation on multiple tyrosine residues, SH2D3A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_005481
Immunogen: Synthetic peptide of human SH2D3A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
Cellular Localization: Other locations:intracellular
Storage: Store at -20C. Avoid freeze / thaw cycles.