Product Type: Antibody
Descritpion: Oligodendrocyte myelin glycoprotein (OMG, OMgp) is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes that influences the development of the adult central nervous system (CNS). OMG inhibits neurite outgrowth through its interaction with the Nogo receptor. This function requires its leucine-rich repeat domain, a highly-conserved region in OMG that influences cell proliferation, formation and maintenance of myelin sheaths. OMG inhibits neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC-12 cells.
Research Areas: Neuroscience
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_002535
Immunogen: Synthetic peptide of human OMG
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Oligodendrocytes and myelin of the central nervous system.
Cellular Localization: Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.