CYP1A1 Polyclonal AntibodyE-AB-16676
Product Type: Antibody
Descritpion: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: NP_000490
Immunogen: Synthetic peptide of human CYP1A1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control: Lung, lymphocytes and placenta.
Cellular Localization: Endoplasmic reticulum membrane. Microsome membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-cyp1a1_polyclonal_antibody-36071.html
Manual Link: https://www.elabscience.com/viewpdf-36071-elabscience-E-AB-16676.PDF