Product Type: Antibody
Descritpion: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001098101
Immunogen: Synthetic peptide of human PDE4D
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 91kDa
Tissue Specificity/Positive Control: Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Cellular Localization: Cytoplasm. Membrane. Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.
Storage: Store at -20C. Avoid freeze / thaw cycles.