Product Type: Antibody
Descritpion: The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_001166169
Immunogen: Synthetic peptide of human PPARGC1B
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Ubiquitous with higher expression in heart, brain and skeletal muscle.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.