MED12 Polyclonal AntibodyE-AB-16943
Product Type: Antibody
Descritpion: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along witHuman, MouseED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_005111
Immunogen: Synthetic peptide of human MED12
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Ubiquitous.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-med12_polyclonal_antibody-36338.html
Manual Link: https://www.elabscience.com/viewpdf-36338-elabscience-E-AB-16943.PDF