Product Type: Antibody
Descritpion: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
Research Areas: Cancer, Cell Biology, Cardiovascular, Metabolism
Recommended Dilutions: IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Gene Accession: BC017296
Immunogen: Full length fusion protein
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Widely expressed.
Cellular Localization: Nucleus,Other locations:cytoplasm,TORC2 complex
Storage: Store at -20C. Avoid freeze / thaw cycles.