ELOC Polyclonal Antibody

ELOC Polyclonal Antibody

E-AB-17057

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Research Areas: Epigenetics and Nuclear Signaling
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:30-150, ELISA 1:2000-10000
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: Q15369
Gene Accession: BC013809
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Full length fusion protein
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.1 Publication
Cellular Localization: Cytosol,Nucleus,elongin complex,nucleoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-eloc_polyclonal_antibody-36452.html
Manual Link: https://www.elabscience.com/viewpdf-36452-elabscience-E-AB-17057.PDF