TRIB2 Polyclonal AntibodyE-AB-17147
Product Type: Antibody
Descritpion: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Research Areas: Cancer, Cardiovascular, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:30-150, ELISA 1:2000-10000
Size: 200 uL
Gene Accession: BC002637
Immunogen: Full length fusion protein
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Highly expressed in peripheral blood leukocytes.
Cellular Localization: Cytoplasm. Cytoplasm>cytoskeleton. May associate with the cytoskeleton.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-trib2_polyclonal_antibody-36542.html
Manual Link: https://www.elabscience.com/viewpdf-36542-elabscience-E-AB-17147.PDF