TWIST2 Polyclonal AntibodyE-AB-17175
Product Type: Antibody
Descritpion: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Stem cells
Recommended Dilutions: IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Gene Accession: BC017907
Immunogen: Full length of human TWIST2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.
Cellular Localization: Nucleus. Cytoplasm. Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-twist2_polyclonal_antibody-36570.html
Manual Link: https://www.elabscience.com/viewpdf-36570-elabscience-E-AB-17175.PDF