ERBB2 Polyclonal AntibodyE-AB-17300
Product Type: Antibody
Descritpion: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
Research Areas: Cancer, Immunology, Signal transduction, Tags & Cell Markers
Recommended Dilutions: WB 1:200-1000, ELISA 1:1000-2000
Size: 200 uL
Gene Accession: NP_004439
Immunogen: Synthetic peptide of human ERBB2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 138 kDa
Tissue Specificity/Positive Control: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Cellular Localization: Cytoplasm. Nucleus and Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-erbb2_polyclonal_antibody-36695.html
Manual Link: https://www.elabscience.com/viewpdf-36695-elabscience-E-AB-17300.PDF