CHEK1 Polyclonal AntibodyE-AB-17303
Product Type: Antibody
Descritpion: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:200-1000, ELISA 1:1000-2000
Size: 200 uL
Gene Accession: NP_001265
Immunogen: Synthetic peptide of human CHEK1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 54 kDa
Tissue Specificity/Positive Control: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon.
Cellular Localization: Cytoskeleton,centrosome,Cytosol,Extracellular region or secreted,extracellular space,Nucleus,condensed nuclear chromosome,nucleoplasm,nucleus,Other locations:chromatin,cytoplasm,intracellular membrane-bounded organelle,protein complex
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-chek1_polyclonal_antibody-36698.html
Manual Link: https://www.elabscience.com/viewpdf-36698-elabscience-E-AB-17303.PDF