RCC1 Polyclonal AntibodyE-AB-17425
Product Type: Antibody
Descritpion: RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor, deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.
Research Areas: Cancer, Cell Biology
Recommended Dilutions: WB 1:200-1000, ELISA 1:1000-2000
Size: 200 uL
Gene Accession: NP_001041659
Immunogen: Synthetic peptide of human RCC1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 45 kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus. Cytoplasm. Becomes dispersed throughout the cytoplasm during mitosis.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rcc1_polyclonal_antibody-36820.html
Manual Link: https://www.elabscience.com/viewpdf-36820-elabscience-E-AB-17425.PDF