Product Type: Antibody
Descritpion: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
Research Areas: Cancer, Cell Biology, Cardiovascular, Signal transduction
Recommended Dilutions: IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Gene Accession: NP_000497
Immunogen: Synthetic peptide of human F2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed by the liver and secreted in plasma.
Cellular Localization: Secreted, extracellular space.
Storage: Store at -20C. Avoid freeze / thaw cycles.