Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Research Areas: Cancer, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-2000, IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Gene Accession: NP_055047
Immunogen: Synthetic peptide of human VAMP2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 13 kDa
Tissue Specificity/Positive Control: Nervous system and skeletal muscle.
Cellular Localization: Cytoplasmic vesicle>secretory vesicle>synaptic vesicle membrane. Cell junction>synapse>synaptosome. Neuronal synaptic vesicles.
Storage: Store at -20C. Avoid freeze / thaw cycles.