VPS4A Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
Research Areas: Cancer, Cell Biology, Microbiology, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-2000, IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Concentration: 0.5mg/mL
Swissprot: Q9UN37
Gene Accession: NP_037377
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human VPS4A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 49 kDa
Tissue Specificity/Positive Control: Ubiquitously expressed.
Cellular Localization: Prevacuolar compartment membrane. Late endosome membrane. Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-vps4a_polyclonal_antibody-36951.html
Manual Link: https://www.elabscience.com/viewpdf-36951-elabscience-E-AB-17556.PDF