WWOX Polyclonal AntibodyE-AB-17624
Product Type: Antibody
Descritpion: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience
Recommended Dilutions: WB 1:500-2000, ELISA 1:2000-5000
Size: 200 uL
Gene Accession: NP_057457
Immunogen: Synthetic peptide of human WWOX
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 47 kDa
Tissue Specificity/Positive Control: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Cellular Localization: Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-wwox_polyclonal_antibody-37019.html
Manual Link: https://www.elabscience.com/viewpdf-37019-elabscience-E-AB-17624.PDF