Phospho-AMPK beta1 (Ser182) Polyclonal AntibodyE-AB-20807
Product Category: Phospho/Acetyl/Methyl
Description: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Gene ID: 5564
Immunogen: Synthesized peptide derived from human AMPK?1 around the phosphorylation site of Ser182
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 38kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytosol,Nucleus,nucleoplasm,Other locations:nucleotide-activated protein kinase complex
Product Link: https://www.elabscience.com/p-phospho_ampk_beta1_(ser182)_polyclonal_antibody-25396.html
Manaul Link: https://www.elabscience.com/viewpdf-25396-elabscience-E-AB-20807.PDF