Phospho-FAK (Tyr397) Polyclonal AntibodyE-AB-21093
Product Category: Phospho/Acetyl/Methyl
Description: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Research Areas: Cancer, Cardiovascular, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Gene ID: 5747
Immunogen: Synthesized peptide derived from human FAK around the phosphorylation site of Tyr397
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 119kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cell junction>focal adhesion. Cell membrane. Constituent of focal adhesions.
Product Link: https://www.elabscience.com/p-phospho_fak_(tyr397)_polyclonal_antibody-25682.html
Manaul Link: https://www.elabscience.com/viewpdf-25682-elabscience-E-AB-21093.PDF