Phospho-PGR (Ser400) Polyclonal AntibodyE-AB-21102
Product Category: Phospho/Acetyl/Methyl
Description: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000
Gene ID: 5241
Immunogen: Synthesized peptide derived from human PR around the phosphorylation site of S400.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 99kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases; Mitochondrion outer membrane and Nucleus. Cytoplasm. Mainly nuclear.
Product Link: https://www.elabscience.com/p-phospho_pgr_(ser400)_polyclonal_antibody-25691.html
Manaul Link: https://www.elabscience.com/viewpdf-25691-elabscience-E-AB-21102.PDF