Phospho-WASF1 (Tyr125) Polyclonal AntibodyE-AB-21184
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.WASF1 (WAS Protein Family Member 1) is a Protein Coding gene. Diseases associated with WASF1 include Wiskott-Aldrich Syndrome and Spinocerebellar Ataxia With Axonal Neuropathy Type 2. Among its related pathways are Innate Immune System and RET signaling. GO annotations related to this gene include actin binding and Rac GTPase binding. An important paralog of this gene is WASF2.
Research Areas: Cancer, Metabolism, Neuroscience, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Gene ID: 8936
Immunogen: Synthesized peptide derived from human WAVE1 around the phosphorylation site of Tyr125
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 70kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm>cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
Product Link: https://www.elabscience.com/p-phospho_wasf1_(tyr125)_polyclonal_antibody-25773.html
Manaul Link: https://www.elabscience.com/viewpdf-25773-elabscience-E-AB-21184.PDF