Phospho-P63 (Ser455) Polyclonal AntibodyE-AB-21192
Product Category: Phospho/Acetyl/Methyl
Description: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Gene ID: 8626
Immunogen: Synthesized peptide derived from human p63 around the phosphorylation site of Ser455
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 70kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus
Product Link: https://www.elabscience.com/p-phospho_p63_(ser455)_polyclonal_antibody-25781.html
Manaul Link: https://www.elabscience.com/viewpdf-25781-elabscience-E-AB-21192.PDF