Phospho-PTPN1 (Ser50) Polyclonal Antibody

Phospho-PTPN1 (Ser50) Polyclonal Antibody

E-AB-21203

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Cardiovascular, Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,IHC-p,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Clonality: Polyclonal
Clone No:
SwissProt: P18031
Gene ID: 5770
Reactivity: Human,Mouse,Rat,Monkey
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human PTP1B around the phosphorylation site of Ser50
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 49kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Endoplasmic reticulum membrane.

Product Link: https://www.elabscience.com/p-phospho_ptpn1_(ser50)_polyclonal_antibody-25792.html
Manaul Link: https://www.elabscience.com/viewpdf-25792-elabscience-E-AB-21203.PDF