Phospho-c-Fms (Tyr561) Polyclonal AntibodyE-AB-21206
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Research Areas: Cancer, Cardiovascular, Immunology, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Gene ID: 1436
Immunogen: Synthesized peptide derived from human c-Fms around the phosphorylation site of Tyr561
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 130kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Membrane.
Product Link: https://www.elabscience.com/p-phospho_c_fms_(tyr561)_polyclonal_antibody-25795.html
Manaul Link: https://www.elabscience.com/viewpdf-25795-elabscience-E-AB-21206.PDF