Phospho-RPS6KA5 (Ser212) Polyclonal AntibodyE-AB-21230
Product Category: Phospho/Acetyl/Methyl
Description: Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Gene ID: 9252
Immunogen: Synthesized peptide derived from human MSK1 around the phosphorylation site of S212.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 90kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Cytoplasm. Predominantly nuclear. Partially cytoplasmic.
Product Link: https://www.elabscience.com/p-phospho_rps6ka5_(ser212)_polyclonal_antibody-25819.html
Manaul Link: https://www.elabscience.com/viewpdf-25819-elabscience-E-AB-21230.PDF