Phospho-p16 (Ser326) Polyclonal AntibodyE-AB-21246
Product Category: Phospho/Acetyl/Methyl
Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Gene ID: 1029
Immunogen: Synthesized peptide derived from human p16 around the phosphorylation site of Ser326
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 20kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasmic and Nuclear
Product Link: https://www.elabscience.com/p-phospho_p16_(ser326)_polyclonal_antibody-25835.html
Manaul Link: https://www.elabscience.com/viewpdf-25835-elabscience-E-AB-21246.PDF