Phospho-IGF1R (Tyr1161) Polyclonal Antibody

Phospho-IGF1R (Tyr1161) Polyclonal Antibody

E-AB-21270

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like rowth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades,thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine-binding (PTB) domains of Insulin receptor substrates (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into ? and ? subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid ransmembrane protein.
Research Areas: Cancer, Developmental biology, Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,IHC-p,IF,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Clonality: Polyclonal
Clone No:
SwissProt: P08069,P06213
Gene ID: 3480
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human IGF-IR around the phosphorylation site of Tyr1161
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 95kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Endosome,endosome membrane,Extracellular region or secreted,extracellular exosome,Plasma Membrane,caveola,dendrite membrane,external side of plasma membrane,insulin receptor complex,integral component of plasma membrane,neuronal cell body membrane,plasma membrane,Other locations:intracellular,membrane,receptor complex

Product Link: https://www.elabscience.com/p-phospho_igf1r_(tyr1161)_polyclonal_antibody-25859.html
Manaul Link: https://www.elabscience.com/viewpdf-25859-elabscience-E-AB-21270.PDF