Phospho-Histone H2A.X (Tyr142) Polyclonal AntibodyE-AB-21331
Product Category: Phospho/Acetyl/Methyl
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:1000-2000
Gene ID: 3014
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 15kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Chromosome.
Product Link: https://www.elabscience.com/p-phospho_histone_h2a.x_(tyr142)_polyclonal_antibody-25387.html
Manaul Link: https://www.elabscience.com/viewpdf-25387-elabscience-E-AB-21331.PDF