Product Category: Phospho/Acetyl/Methyl
Description: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
Research Areas: Cancer, Signal transduction
Size: 200 uL
Recommended Dilutions: IHC 1:100-200
Clone No: Clone:1D4
Gene ID: 197259
Immunogen: Synthetic Peptide of Phospho-MLKL (Ser358)
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Protein A purification
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytosol,Plasma Membrane,Other locations:cytoplasm