Phospho-Tau (Thr205) Polyclonal AntibodyE-AB-21370
Product Category: Phospho/Acetyl/Methyl
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Research Areas: Cancer, Neuroscience, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Gene ID: 4137
Immunogen: Synthesized peptide derived from human Tau around the phosphorylation site of Thr205
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 79kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm>cytosol. Cell membrane. Cytoplasm>cytoskeleton. Cell projection>axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Product Link: https://www.elabscience.com/p-phospho_tau_(thr205)_polyclonal_antibody-41103.html
Manaul Link: https://www.elabscience.com/viewpdf-41103-elabscience-E-AB-21370.PDF