Phospho-FADD (Ser194) Polyclonal AntibodyE-AB-21437
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Research Areas: Cancer, Cell Biology
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Gene ID: 8772
Immunogen: Synthesized peptide derived from human FADD around the phosphorylation site of Ser194
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 28kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytosol,ripoptosome,Nucleus,Plasma Membrane,CD95 death-inducing signaling complex,death-inducing signaling complex,plasma membrane,Other locations:cell body,cytoplasm,membrane raft,neuron projection
Product Link: https://www.elabscience.com/p-phospho_fadd_(ser194)_polyclonal_antibody-41140.html
Manaul Link: https://www.elabscience.com/viewpdf-41140-elabscience-E-AB-21437.PDF