Phospho-POLR2A (Ser1619) Polyclonal AntibodyE-AB-21470
Product Category: Phospho/Acetyl/Methyl
Description: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Gene ID: 5430
Immunogen: Synthesized peptide derived from human Rpb1 around the phosphorylation site of Ser1619
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 250kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus.
Product Link: https://www.elabscience.com/p-phospho_polr2a_(ser1619)_polyclonal_antibody-41112.html
Manaul Link: https://www.elabscience.com/viewpdf-41112-elabscience-E-AB-21470.PDF