Phospho-ATM (Ser1981) Polyclonal AntibodyE-AB-21540
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000
Gene ID: 472
Immunogen: Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 350kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Product Link: https://www.elabscience.com/p-phospho_atm_(ser1981)_polyclonal_antibody-41265.html
Manaul Link: https://www.elabscience.com/viewpdf-41265-elabscience-E-AB-21540.PDF