Phospho-p70 S6 kinase alpha (Ser427) Polyclonal AntibodyE-AB-21883
Product Category: Phospho/Acetyl/Methyl
Description: P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Size: 200 uL
Recommended Dilutions: IHC 1:100-1:300, ELISA 1:40000
Gene ID: 6198
Immunogen: Synthesized peptide derived from human p70 S6 kinase ? around the phosphorylation site of S427.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 70kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm; Nucleus. Cytoplasm and Cell junction>synapse>synaptosome. Mitochondrion outer membrane.
Product Link: https://www.elabscience.com/p-phospho_p70_s6_kinase_alpha_(ser427)_polyclonal_antibody-41826.html
Manaul Link: https://www.elabscience.com/viewpdf-41826-elabscience-E-AB-21883.PDF