Phospho-TOP2A (Ser1525) Polyclonal AntibodyE-AB-21933
Product Category: Phospho/Acetyl/Methyl
Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Gene ID: 7153
Immunogen: Synthesized peptide derived from human Topo II? around the phosphorylation site of S1525.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 190kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm. Nucleus>nucleoplasm. Generally located in the nucleoplasm.
Product Link: https://www.elabscience.com/p-phospho_top2a_(ser1525)_polyclonal_antibody-41831.html
Manaul Link: https://www.elabscience.com/viewpdf-41831-elabscience-E-AB-21933.PDF