Claudin 18 Monoclonal AntibodyE-AB-27102
Product Type: monoclonal antibody
Clone No: Clone:99
Description: Claudin 18 (CLDN18) belongs to the large claudin family of proteins,which are tetraspan transmembrane proteins of tight junctions . Claudins exhibit specific patterns of expression in different tissues . CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition,whereas CLDN18.1 is lung specific . Altered CLDN18 expression has been reported in various human malignancies,including gastric cancer,lung adenocarcinoma,and pancreatic neoplasm .
Research Areas: Cancer, Signal transduction
Size: 200 uL
Gene ID: 51208
Recommended Dilutions: IHC 1:200-1:1200
Immunogen: Fusion protein of Claudin 18
Formulation: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Purification: Protein A purification
Calculated MW: 261aa, 28kDa
Obeserved MW: 29kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Tissue Specificity/Positive Control: Concentrated at the cell-cell borders of epithelial cells.
Cellular Localization: Cell junction>tight junction. Cell membrane.
Product Link: https://www.elabscience.com/p-claudin_18_monoclonal_antibody-24849.html
Manual Link: https://www.elabscience.com/viewpdf-24849-elabscience-E-AB-27102.PDF