MUC16 Monoclonal AntibodyE-AB-27252
Product Type: monoclonal antibody
Clone No: Clone:3012
Description: MUC16,also named as CA125,is thought to provide a protective,lubricating barrier against particles and infectious agents at mucosal surfaces. It is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein,although estimates of its size range from 200 to 2000 kDa with smaller “subunits” being described by some investigators. The antibody recognizes the C-term of MUC16.
Research Areas: Cancer, Immunology, Signal transduction, Tags & Cell Markers
Size: 200 uL
Gene ID: 94025
Recommended Dilutions: IHC 1:20-1:200
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Purification: Protein G purification
Calculated MW: 2353kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Tissue Specificity/Positive Control: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Cellular Localization: Cell membrane. Secreted>extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Product Link: https://www.elabscience.com/p-muc16_monoclonal_antibody-24999.html
Manual Link: https://www.elabscience.com/viewpdf-24999-elabscience-E-AB-27252.PDF