Product Type: Antibody
Descritpion: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Research Areas: Cancer, Cell Biology, Metabolism
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-1
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 45kDa
Tissue Specificity/Positive Control: Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Cellular Localization: Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.