Product Type: Antibody
Descritpion: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Research Areas: Cancer, Cell Biology, Metabolism
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-9 p35
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 46kDa
Tissue Specificity/Positive Control: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Cellular Localization: Cytosol,apoptosome,cytosol,Mitochondrion,Nucleus,Other locations:protein complex
Storage: Store at -20C. Avoid freeze / thaw cycles.