Cleaved-CASP9 p35 (D315) Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Research Areas: Cancer, Cell Biology, Metabolism
Applications: WB,IHC-p,IF,ELISA
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Size: 200 uL
Concentration: 1mg/mL
Swissprot: P55211
Gene Accession:
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-9 p35
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 46kDa
Tissue Specificity/Positive Control: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Cellular Localization: Cytosol,apoptosome,cytosol,Mitochondrion,Nucleus,Other locations:protein complex
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-cleaved_casp9_p35_(d315)_polyclonal_antibody-26336.html
Manual Link: https://www.elabscience.com/viewpdf-26336-elabscience-E-AB-30011.PDF