Product Category: Phospho/Acetyl/Methyl
Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:10000
Gene ID: 8350/8351/8352/8353/8354/8355/8356/8357/8358/8968/126961/333932/653604/3020/3021/440093
Immunogen: Synthesized peptide derived from the N-terminal region of human Histone H3 around the di-methylation site of K10.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 17kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Extracellular region or secreted,extracellular exosome,extracellular region,Nucleus,nuclear chromosome,nuclear chromosome, telomeric region,nuclear nucleosome,nucleoplasm,nucleus,Other locations:nucleosome,protein complex