Product Type: Antibody
Descritpion: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Stem cells
Recommended Dilutions: WB 1:500-1:2000, IF 1:50-1:200, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human RUNX2.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 57kDa
Tissue Specificity/Positive Control: Specifically expressed in osteoblasts.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.