STX1A Polyclonal Antibody
STX1A Polyclonal Antibody

STX1A Polyclonal Antibody

E-AB-30185

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Metabolism, Neuroscience, Signal transduction
Applications: IHC-p,ELISA
Recommended Dilutions: IHC 1:100-1:300 ELISA 1:20000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q16623
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human Syntaxin 1.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 33kDa
Tissue Specificity/Positive Control: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Cellular Localization: Secreted and Cytoplasmic vesicle>secretory vesicle>synaptic vesicle membrane. Cell junction>synapse>synaptosome.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-stx1a_polyclonal_antibody-26510.html
Manual Link: https://www.elabscience.com/viewpdf-26510-elabscience-E-AB-30185.PDF