Product Type: Antibody
Descritpion: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction, Stem cells
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human Glut4.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 55kDa
Tissue Specificity/Positive Control: Skeletal and cardiac muscles; brown and white fat.
Cellular Localization: Cell membrane. Endomembrane system. Cytoplasm, perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
Storage: Store at -20C. Avoid freeze / thaw cycles.