TP53BP1 Polyclonal AntibodyE-AB-30372
Product Type: Antibody
Descritpion: TP53BP1 (tumor protein p53 binding protein 1) is a protein-coding gene. Go annotations related to this gene include methylated histone residue binding and p53 binding.Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis.Enhances TP53-mediated transcriptional activation.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from human 53BP1 around the non-phosphorylation site of Ser6.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 214kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus. Chromosome>centromere>kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-tp53bp1_polyclonal_antibody-26697.html
Manual Link: https://www.elabscience.com/viewpdf-26697-elabscience-E-AB-30372.PDF