ALDOA Polyclonal AntibodyE-AB-30476
Product Type: Antibody
Descritpion: The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
Research Areas: Cancer, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human Aldolase A
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 39kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoskeleton,actin cytoskeleton,Cytosol,Extracellular region or secreted,extracellular exosome,extracellular region,extracellular space,Nucleus,Other locations:ficolin-1-rich granule lumen,I band,M band,membrane,platelet alpha granule lumen,secretory granule lumen,sperm head,tertiary granule lumen
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-aldoa_polyclonal_antibody-26801.html
Manual Link: https://www.elabscience.com/viewpdf-26801-elabscience-E-AB-30476.PDF