Product Type: Antibody
Descritpion: In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene.CNGB1 (Cyclic Nucleotide Gated Channel Beta 1) is a Protein Coding gene. Diseases associated with CNGB1 include Retinitis Pigmentosa 45 and Cngb1-Related Retinitis Pigmentosa. Among its related pathways are Phototransduction and Metabolism of fat-soluble vitamins. GO annotations related to this gene include voltage-gated potassium channel activity and cGMP binding. An important paralog of this gene is CNGB3.
Research Areas: Neuroscience, Signal transduction, Stem cells
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human CNG-1?
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 102kDa
Tissue Specificity/Positive Control:
Cellular Localization: Membrane; Multi-pass membrane protein.
Storage: Store at -20C. Avoid freeze / thaw cycles.