Product Type: Antibody
Descritpion: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
Research Areas: Cancer, Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Lck around the non-phosphorylation site of S540.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control: Expressed specifically in lymphoid cells.
Cellular Localization: Cytoplasm. Cell membrane. Present in lipid rafts in an unactive form.
Storage: Store at -20C. Avoid freeze / thaw cycles.